Date: Thu, 18 Dec 1997 20:08:42 GMT Server: Apache/1.1.3 Content-type: text/html Content-length: 10112 Last-modified: Fri, 07 Nov 1997 21:39:10 GMT Non-Invasive Monitoring Systems, Inc.
Non-Invasive Monitoring Systems, Inc. (Nims)

Nims' Strong Patent & Proprietary Positions on 510(k) Products

 

    Patents on hardware 

    • Basic hardware.
    • Improved circuitry for stability on basic  hardware
    • Respibands. 
   Patents on Respitrace software  
  • Automatic calibration technique: for apnea discrimination & changes of tidal volume.
  • Algorithm to distinguish central, mixed and obstructive apneas.
  • Algorithm to detect motion artifacts in Pulse Oximetry wave form. 
 
Patented Products Documented in Medical Literature not yet Submitted to FDA
 
Non-Invasive Central Venous Pressure Monitor (CVP)  
  • Hardware for neck inductive plethysmograph, the sensor utilized, RespiTrak, has 510(k) approval for marketing. Software requires submission to FDA.
  • CVP measurement based upon well-known clinical observation that raising level of upper torso of supine subject causes collapse of internal jugular veins. 
  • Collapse point is the height above mid-chest level that the venous pulse measure with NIP is replaced by an arterial pulse.
  • Scientific study has established validity to invasive measurement of CVP (Chest 1991;100:371).

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Non-Invasive Monitor of Ventricular Volume Curves (Thoracocardiography [TCG])  
  • Uses inductive plethysmographic band placed around chest below xiphoid process as sensor.
  • Depicts ventricular volume curve which strongly resembles ventricular volume curve obtained simultaneously with Automatic Border Edge Detection Echocardiogram.
  • Measures changes in stroke volume & cardiac output.
  • Provides measures of systolic & diastolic function.
  • Four papers on TCG technology in peer-reviewed journals (Chest 1991;99:613; Chest 1991; 99:896;  Chest 1994;106:1668; Am.J.Respir.Dis Crit.Care Med. 1997;155:26).
  • TCG compares well to thermodilution determined cardiac output in critically ill ICU patients over several hours.
  • TCG compares well to systolic time intervals obtained from carotid pulse.
  • Derivative of diastolic portion of ventricular volume curve (TCG) corresponds to Echo-Doppler E&A waves; deceleration time of E wave correlates with Pulmonary Capillary Wedge Pressure. Therefore, TCG might be a non-invasive alternative to Swan-Ganz catheter! 

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